Effect of Carbohydrate Type on Brain Composition and Senescence in Aging, Hyperinsulinemia-prone OBESE LA/Ntul//-cp Rats

To determine if phenotype and the carbohydrate type resulted in alterations brain composition obese of congenic LA/Ntul//-cp rat, groups (n= 8 rats/group) male littermate lean rats were fed standardized isocaloric diets containing 54% (w/w) cornstarch (ST diet) or sucrose (SUC from 1 until 10.5 ± 0.5 months age. The his strain develops early onset chronic hyperinsulinemia without NIDDM associated with hypertrophic-hyperplastic obesity during postweaning growth. Brain tissues dissected, representative aliquots subjected to total fat, protein, DNA analysis. Body weights >> greater when SUC than ST diet both phenotypes. mass > obese, was modestly lower diet. Protein content Lower phenotypes, but percent lipid proportional mass. Total body fat significantly occurred littermates only These results indicate that growth cellular development is impaired aging, hyperinsulinemia-prone this strain, further diets, decreased parameters likely a neuronal inflammatory syndrome common excessive accretion obesity, resulting premature senescence.